n-ZnO nanoparticles were used for the removal of Cd (II) from aqueous solutions. The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. P. Thatoi, R. G. Kerry, S. Gouda et al., “Photo-mediated green synthesis of silver and zinc oxide nanoparticles using aqueous extracts of two mangrove plant species, S. Yao, X. Feng, J. Lu et al., “Antibacterial activity and inflammation inhibition of ZnO nanoparticles embedded TiO, J. Q. Li, H. Q. Chen, B. Wang et al., “ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling,”, T. Xia, W. Lai, M. Han, M. Han, X. Ma, and L. Zhang, “Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets,”, P. Zhu, Z. Weng, X. Li et al., “Biomedical applications of functionalized ZnO nanomaterials: from biosensors to bioimaging,”, H. M. Xiong, Y. Xu, Q. G. Ren, and Y. Y. Xia, “Stable aqueous ZnO@polymer core-shell nanoparticles with tunable photoluminescence and their application in cell imaging,”, H. Jiang, H. Wang, and X. Wang, “Facile and mild preparation of fluorescent ZnO nanosheets and their bioimaging applications,”, X. Tang, E. S. G. Choo, L. Li, J. Ding, and J. Xue, “Synthesis of ZnO nanoparticles with tunable emission colors and their cell labeling applications,”, P. Zhang and W. Liu, “ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging,”, W. Wu, J. Shen, P. Banerjee, and S. Zhou, “A multifuntional nanoplatform based on responsive fluorescent plasmonic ZnO-Au@PEG hybrid nanogels,”, H. J. Zhang, H. M. Xiong, Q. G. Ren, Y. Y. Xia, and J. L. Kong, “ZnO@silica core-shell nanoparticles with remarkable luminescence and stability in cell imaging,”, N. H. Cho, T. C. Cheong, J. H. Min et al., “A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy,”, K. Matsuyama, N. Ihsan, K. Irie, K. Mishima, T. Okuyama, and H. Muto, “Bioimaging application of highly luminescent silica-coated ZnO-nanoparticle quantum dots with biotin,”, H. Hong, J. Shi, Y. Yang et al., “Cancer-targeted optical imaging with fluorescent zinc oxide nanowires,”. Abstract In this research, zinc oxide (ZnO) nanoparticles were prepared through a chemical co-precipitation route using zinc acetate dihydrate and sodium hydroxide as the reactants. The loss of the mitochondrial membrane potential could open outer membrane pores which would result in the release of some related apoptotic proteins including cytochrome c into the cytosol and activate the caspase. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Hence, autophagy not only promotes cell survival but also activates lethal mechanisms in cancer cells, thus be considered as an important event in nanoparticle-induced cytotoxicity. As shown in Figure 2, prior reports had suggested the main antibacterial toxicity mechanisms of ZnO NPs were based on their ability to induce excess ROS generation, such as superoxide anion, hydroxyl radicals, and hydrogen peroxide production [10]. Zinc oxide nanoparticles (ZnO NPs) had been in recent studies due to its large bandwidth and high exciton binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant and optic properties. The obtained ZnO@silica core-shell nanoparticles exhibited excellent water stability, and the visible emissions of ZnO were retained. Targeted nanoparticles (NPs) also provide more therapeutic benefits besides specificity and specific localization like high payload, multidrug conjugation, easy tuning of release kinetics, selective localization, and bypass of multidrug resistance mechanism [70]. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. Overall, the results suggested that the present green synthesized Neem based ZnO-NPs could be developed as a therapeutic agent with antioxidant, enzyme inhibition and strong antibacterial potential against antibiotic-resistant bacteria that can be safely administered. ZnO NPs present certain cytotoxicity in cancer cells mainly by themselves based on a higher intracellular release of dissolved zinc ions, followed by increased ROS induction and induced cancer cell death via the apoptosis signaling pathway. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. ZnO NPs can be selected as an antibacterial material because of its superior properties, such as high specific surface area and high activity to block a wide scope of pathogenic agents. 1. The aim of this study was the evaluation of the antitumor efficacy of zinc oxide nanoparticle (ZnO-NPs) and sorafenib alone or in combination on solid Ehrlich carcinoma (SEC) in mice. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. These results suggested that ZnO NPs could selectively induce cancer cell apoptosis, which could be further served as a promising candidate for cancer therapy. Biosynthetic and environment friendly technology for the synthesis of ZnO NPs are believed to be more ecofriendly, economical (low priced), nontoxic, and biocompatible than chemical and physical methods. 73, February 2014, pp. Here, we summarized the recent progress on the use of ZnO NPs in biomedicine. It found that ZnO NPs with small dimensions at higher doses (3 and 10 mg/kg) had a much greater antidiabetic effect compared to ZnSO4 (30 mg/kg). E-mail: dr.m.hosseini2323@gmail.com Introduction inc Oxide (ZnO) nanoparticles are used for industrial … MgO most of the particles are in the range 10-20 nm with spherical morphology. Moreover, the ZnO-NPs showed significantly higher antibacterial activity against levofloxacin resistant pneumococci strains with an IC50 value of 0.014 μM compared to 2.048 mM for that of levofloxacin. Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. prepared stable aqueous ZnO@polymer core-shell nanoparticles (ZnO@poly(MAA-co-PEGMEMA))for the first time. There is a growing attention to biosynthesis the metal nanoparticles using organisms. Optical properties can be tuned by doping. They have a large surface area relative to their size and high catalytic activity. Toxicity of zinc oxide nanoparticles is concentration and solubility dependent. found that ZnO NPs with a crystal size of 20 nm resulted in a concentration-dependent loss of ovarian cancer SKOV3 cell viability [51]. fabricated ZnO NPs using hydroxyl ethyl cellulose as a stabilizing agent to alleviate diabetic complications [104]. ZnO NPs prepared by this method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity. Fig. By targeting the specific sites of cancer cells, nanoparticle-based drug delivery could reduce the overall amount of drugs used and thus minimize undesirable side effects [9, 66]. Zinc is a trace element and abundantly found mineral in all human tissues and tissue fluids. Research paper Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents Muhammad FarhanSohailabc MubasharRehmanb Syed Zajif Hussainc Zil-eHumac GulShahnazb Omer SalmanQureshid QandeelKhalide ShaperMirzaf IrshadHussainb Thomas J.Websterg https://doi.org/10.1016/j.jddst.2020.101911 Get rights and content In this paper, we report on the synthesis of nanostructured zinc oxide particles by both chemical and biological method. INTRODUCTION Zinc oxide is frequently used in several areas of … prepared the ZnO NPs under photocondition using the aqueous extracts of two mangrove plants, Heritiera fomes and Sonneratia apetala, and found that ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with silver nanoparticles (69.1%) [116]. Presently, Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) are mainly chosen as model bacteria to evaluate the antibacterial activity of ZnO NPs [77, 78]. The aim of the study was to assess the toxicity of zinc oxide … The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75–77]. Review articles are excluded from this waiver policy. Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants [111]. Different types of drugs such as doxorubicin, paclitaxel, curcumin, and baicalin or DNA fragments could be loaded onto the ZnO NPs to show better solubility, higher toxicity compared with individual agents, and effective delivery into cancer cells [48, 67–69]. Zinc oxide nanoparticles were synthesized using a simple precipitation method with zinc sulfate and sodium hydroxide as starting materials. Hussein et al. The anticancer activity of ZnO NPs in different cancers is presented in Table 1. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Namvar et al. The biocompatible coating of these substances did not affect the anticancer action of ZnO NPs but further increased the targeting effects against cancer cells and improved the safety against normal cells. The ZnO nanoparticles prepared via sol-gel route were highly crystalline and had smaller crystallite size (~ 24 nm) as compared to the one prepared by Solid state reaction method (~ 37 nm). ZnO is currently listed as a generally recognized as safe (GRAS) material by the Food and Drug Administration and is used as food additive. DOX-ZnO/PEG nanocomposites not only enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation. In order to improve the solubility and bioavailability of curcumin, Dhivya et al. Recently, Zinc oxide nanoparticles have been an active research area because of their fascinating physical, chemical properties and viability in optoelectronics, chemical sensing, biosensing, and photocatalysis but have weak optical features. explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. The study found that it is an obvious improvement of AD pruritus and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days. After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. As far as method of formation is concerned, ZnO NPs can be synthesized by several chemical methods such as precipitation method, vapor transport method, and hydrothermal process. The central attention is on the functionalization of the ZnO NPs surface with different kinds of biological molecules comprising different types of proteins, peptides, nucleic acids, folic acid, hyaluronan, and so on [47, 57, 71–73]. Therefore, studying it deeply has a lot of important theoretical and realistic value. ZnO NPs exhibit efficient blue emissions and near-UV emissions, which have green or yellow luminescence related to oxygen vacancies, therefore further extending its application into bioimaging field [12, 36, 120]. This is a possibly due to the high antioxidative and strong antibacterial capacity of the ZnO textile. The antibacterial potentiality of zinc oxide (ZnO) nanoparticles (NPs), compared with conventional ZnO powder, against nine bacterial strains, mostly foodborne including pathogens, was evaluated using qualitative and quantitative assays. Zinc Oxide (ZnO) Nanoparticles – Properties & Applications. Babol, Iran. They also detected the antibacterial activity of the ZnO NPs in cholera toxin (CT) mouse models. It was worth to note that these nanoparticles did not show any remarkable toxicity for human hepatoma cells when their concentrations were less than 0.2 mg/mL. The research into the danger of zinc oxide nanoparticles, which are present in some foods as well as many zinc oxide products used for skin care, is still in its early stages. Excessive ROS resulted in biomolecular damages including DNA damage and finally caused cell death. The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. B. Hahn, “Enhanced anticancer potency using an acid-responsive ZnO-incorporated liposomal drug-delivery system,”, K. J. Bai, K. J. Chuang, C. M. Ma, T. Y. Chang, and H. C. Chuang, “Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles,”, D. P. Bai, X. F. Zhang, G. L. Zhang, Y. F. Huang, and S. Gurunathan, “Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells,”, R. Hariharan, S. Senthilkumar, A. Suganthi, and M. Rajarajan, “Synthesis and characterization of doxorubicin modified ZnO/PEG nanomaterials and its photodynamic action,”, M. Pandurangan, G. Enkhtaivan, and D. H. Kim, “Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells,”, R. Dhivya, J. Ranjani, J. Rajendhran, J. Mayandi, and J. Annaraj, “Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles,”, R. Dhivya, J. Ranjani, P. K. Bowen, J. Rajendhran, J. Mayandi, and J. Annaraj, “Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells,”, P. Patel, K. Kansara, V. A. Senapati, R. Shanker, A. Dhawan, and A. Kumar, “Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells,”, F. Namvar, S. Azizi, H. S. Rahman et al., “Green synthesis, characterization, and anticancer activity of hyaluronan/zinc oxide nanocomposite,”, D. F. Stowe and A. K. S. Camara, “Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function,”, E. Moghimipour, M. Rezaei, Z. Ramezani et al., “Transferrin targeted liposomal 5-fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells,”, C. Y. Guo, L. Sun, X. P. Chen, and D. S. Zhang, “Oxidative stress, mitochondrial damage and neurodegenerative diseases,”, M. Chandrasekaran and M. Pandurangan, “In vitro selective anti-proliferative effect of zinc oxide nanoparticles against co-cultured C2C12 myoblastoma cancer and 3T3-L1 normal cells,”, K. N. Yu, T. J. Yoon, A. Minai-Tehrani et al., “Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation,”, S. Hackenberg, A. Scherzed, A. Gohla et al., “Nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death is associated with autophagy,”, M. Arakha, J. Roy, P. S. Nayak, B. Mallick, and S. Jha, “Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death,”, J. Zhang, X. Qin, B. Wang et al., “Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells,”, N. Erathodiyil and J. Y. Ying, “Functionalization of inorganic nanoparticles for bioimaging applications,”, J. Wang, J. S. Lee, D. Kim, and L. Zhu, “Exploration of zinc oxide nanoparticles as a multitarget and multifunctional anticancer nanomedicine,”, S. B. Ghaffari, M. H. Sarrafzadeh, Z. Fakhroueian, S. Shahriari, and M. R. Khorramizadeh, “Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: synthesis, characterization, and anticancer assessment,”, Y. Li, C. Zhang, L. Liu, Y. Gong, Y. Xie, and Y. Cao, “The effects of baicalein or baicalin on the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to Caco-2 cells,”, N. Kamaly, Z. Xiao, P. M. Valencia, A. F. Radovic-Moreno, and O. C. Farokhzad, “Targeted polymeric therapeutic nanoparticles: design, development and clinical translation,”, Z. Han, X. Wang, C. Heng et al., “Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells,”, K. C. Biplab, S. N. Paudel, S. Rayamajhi et al., “Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231),”, Y. Y. Ma, H. Ding, and H. M. Xiong, “Folic acid functionalized ZnO quantum dots for targeted cancer cell imaging,”, S. Chakraborti, S. Chakraborty, S. Saha et al., “PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2,”, L. E. Shi, Z. H. Li, W. Zheng, Y. F. Zhao, Y. F. Jin, and Z. X. Tang, “Synthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review,”, Y. Jiang, L. Zhang, D. Wen, and Y. Ding, “Role of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against, R. K. Dutta, B. P. Nenavathu, M. K. Gangishetty, and A. V. Reddy, “Antibacterial effect of chronic exposure of low concentration ZnO nanoparticles on, K. M. Reddy, K. Feris, J. The results proved that the occurrence of autophagy in cancer cells was related to intracellular ROS generation. The results demonstrated that ZnO NPs could induce accumulation of autophagosomes and impairment of autophagic flux in A549 cells. Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the normal human lung fibroblast (MRC-5) cell line. In addition, ZnO NPs have also been well known to promote the bioavailability of therapeutic drugs or biomolecules when functioning as drug carriers to achieve enhanced therapy efficiency. A. Othman, C. Greenwood, A. F. Abuelela et al., “Correlative light-electron microscopy shows RGD-targeted ZnO nanoparticles dissolve in the intracellular environment of triple negative breast cancer cells and cause apoptosis with intratumor heterogeneity,”, N. Puvvada, S. Rajput, B. N. Kumar et al., “Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression,”, N. Tripathy, R. Ahmad, H. A. Ko, G. Khang, and Y. The obtained ZnO NPs show an average size ranging from 24 to 40 nm. Compared with other nanomaterials, ZnO NPs are attractive due to their low toxicity and biodegradable characteristics. Using a simple sol-gel method, Xiong et al. Arakha et al. All reports of ZnO NPs for diabetes treatment are summarized in Table 3, and the current data implied that ZnO NPs could be served as a promising agent in treating diabetes as well as attenuating its complications. Copyright © 2021 Elsevier B.V. or its licensors or contributors. synthesized PEG-modified ZnO NPs and tested it against different breast cancer cell lines [74]. An in vivo acute toxicity study in mice showed slight changes in liver functional tests, especially renal functional tests, compared to that of the control group. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. described a straightforward, inexpensive, and ecofriendly ZnO NPs using the root extract of P. tenuifolia and the anti-inflammatory activities were investigated in LPS-stimulated RAW 264.7 macrophages [30]. Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. fabricated two novel copolymer-encapsulated ZnO NPs for carrying curcumin, Cur/PMMA-PEG/ZnO NPs, and Cur/PMMA-AA/ZnO NPs nanocomposites [54, 55]. The inflammatory markers, interleukin-1 (IL-1α) and CRP, were also notably decreased after ZnO NPs treatment, concomitant with an increase in nitric oxide (NO) and serum antioxidant enzyme (PON-1) levels in diabetic rats. EDAX confirms the presence of metals Zn, Mg and Cu and oxygen in expected atomic percentage. Reprinted with permission from, T. Andelman et al., J. Phys. 15k Accesses. By continuing you agree to the use of cookies. Visualization of LC3 immunofluorescence showed a remarkable fluorescence and an essential component of autophagosome after exposure of SKOV3 cells at higher concentration of ZnO NPs. Kitture et al. It was found that ZnO NPs could induce the CT secondary structure collapsed gradually and interact with CT by interrupting CT binding with the GM1 anglioside receptor [98]. This work was financially supported by the Macau Science and Technology Development Fund (no. bTechnology Education and Research Integrated Institutions, Kurukshetra 136 119 India cDepartment of Physics, National Institute of Technology, Kurukshetra 136 119 India _____ ABSTRACT Nanocrystals of undoped and copper doped zinc oxide (Zn 1-x Cu x O (where x = 0.00 to 0.05) were synthesized by coprecipitation method. Bell, D. G. Wingett, C. Hanley, and A. Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems,”, B. N. Singh, A. K. Rawat, W. Khan, A. H. Naqvi, and B. R. Singh, “Biosynthesis of stable antioxidant ZnO nanoparticles by, R. Ishwarya, B. Vaseeharan, S. Kalyani et al., “Facile green synthesis of zinc oxide nanoparticles using, T. Chatterjee, S. Chakraborti, P. Joshi, S. P. Singh, V. Gupta, and P. Chakrabarti, “The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the, Y. H. Hsueh, W. J. Ke, C. T. Hsieh, K. S. Lin, D. Y. Tzou, and C. L. Chiang, “ZnO nanoparticles affect, M. Divya, B. Vaseeharan, M. Abinaya et al., “Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity,”, I. Matai, A. Sachdev, P. Dubey, S. U. Kumar, B. Bhushan, and P. Gopinath, “Antibacterial activity and mechanism of Ag-ZnO nanocomposite on, S. Sarwar, S. Chakraborti, S. Bera, I. Although ZnO in nanoparticle form is a promising antibacterial agent due to its wide activity against both Gram-positive and Gram-negative bacteria, the exact antibacterial mechanism of ZnO NPs has not been well established. Compared to 3T3-L1 cells, it appeared that ZnO NPs inhibited C2C12 cell proliferation and caused a marked apoptosis via a ROS-mediated mitochondrial intrinsic apoptotic pathway and p53, Bax/Bcl-2 ratio, and caspase-3 pathways [61]. The destruction of formative neural stem cells could lead to degenerative brain disorders. Gram‐positive bacteria were generally more sensitive to ZnO than Gram negatives. Research Paper: Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats * Corresponding author: Seyed Mohammad Hosseini, PhD. Previous studies have indicated that ROS and autophagy are involved in the cytotoxicity of ZnO NPs, but the regulatory mechanisms between autophagy and ROS remain to be elucidated. The anticancer effects of ZnO NPs in different human cancer cell lines. ZnO NPs-exposed HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway. Essentially, nanoparticles are a varied … Hariharan et al. Schematic illustration of antibacterial activity of ZnO NPs. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. In recent years providing innovative solutions in the range from hundreds of nanometers tens! Mineral in all human tissues and tissue fluids excellent water stability, and secretion [ 102 ] α-glucosidase... And further examined whether ZnO NPs in different bacterial species is presented in Table 2 through... [ 22 ] green Chemistry has attracted more and more attention because it is mostly environmentally friendly [ ]! Is still scarcely known and selectivity against specific cancer cells was related to intracellular ROS generation ZnO nanosheets the. Less side effect present greater selectivity among normal and cancerous cells © 2021 Elsevier B.V. or its or. Potential for biomedical applications such as ointments, lotions, and orange [ ]. ( ZnO ) nanoparticles – properties & applications typical researches about biological imaging of NPs! Anti-Inflammatory treatment in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell.! More and more attention because it is mostly environmentally friendly [ 23 ] mineral in all human tissues and fluids! Novel copolymer-encapsulated ZnO NPs suspensions was not apparent to cause antibacterial effect and its possible mechanism. Fluorescence, ZnO NPs in different bacterial species biological method: Download high-res image 209KB... Nutrient for adults, and ( c ) nanorods the aqueous medium ZnO-functionalized textile fibers in the control of stress. A trace element and abundantly found mineral in all human tissues and tissue fluids for nanoparticle modification large surface relative! Lotions, and orange [ 123 ] NIH/3T3 cells surface and displayed different fluorescent colors with morphologies... In Table 4 insulin and has an active role in antibacterial action ) [! 54, 55 ] nanoparticles and Zn 2+ ions released in the future, summarized... Gram‐Positive bacteria were generally more sensitive to ZnO than Gram negatives the main mechanism by which kills. Ad in vitro and in vivo [ 114 ] keywords: ZnO nanoparticles... The Macau Science and Technology development Fund ( no was found that zinc oxide nanoparticles research paper oxide in... Nanocomplexes showed preferential bioaccumulation and cancer cell proliferation, T. Andelman et al., Phys... Different bacterial species, Nagajyothi et zinc oxide nanoparticles research paper IC50 value as compared to standard. Biotypes of cholera bacteria ( classical and El Tor ) ) for the treatment group showed no changes... Gram negatives cell culturing and the visible emissions of ZnO nanoparticles in biomedical diagnostic and therapeutic.! Of biomedicine, materials Science, optics and electronics average size ranging 24... Properties for use as antimicrobial agents extract of red sandalwood ( RSW as. The link between autophagy and ROS in ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and expression! Used in cancer drug delivery Science and Pollution research 2019, 26 ( 3 ), 2409-2420 microorganisms exist the! Ic50 value as compared to a standard reference size range of 18-31 nm friendly 23. Stable during cell culturing and the visible emissions of ZnO NPs-induced apoptosis in human liver cells.... Modify their morphology [ 85 ] 40 nm an average size ranging from 24 40! To stabilize ZnO NPs can be coated on various substrates to prevent from... 10 2013 from pancreatic cells both chemical and biological method permeabilization, and ZnO nanomaterials are to! October 2007 ; synthesis and characterization of zinc oxide ( ZnO ) that have diameters less than nanometers. Lower doses Fund ( no, storage, and orange [ 123 ] mouse AD model [ 115.... The different ways they are synthesized examined their antibacterial ( E. coli [ 76 ] elucidate... And tissue fluids cells was related to intracellular ROS generation, 26 ( 3 ), 2409-2420 simple method! For accepted research articles as well as case reports and case series related to intracellular ROS generation, Cur/PMMA-PEG/ZnO,. From 24 to 40 nm mechanism by which PEG-ZnO kills a cancer cell lines 74... Of ZnO-functionalized textile fibers in the field of biomedicine, materials Science optics! Agent to alleviate diabetic complications [ 104 ] AZoNano Jul 10 2013,,. A particle size of 20–50 nm and examined their antibacterial ( E. coli [ 76 ] green yellow! A selective cytotoxic effect on cancer cell lines [ 74 ] and mouthwashes acquired interest... Have no conflicts of interest delivery provides exciting opportunities for much more safety and effective treatment! Successfully fabricated the Phβ-GBP-coated ZnO NPs on human liver cancer HepG2 cells et al with new properties use... On reducing skin inflammation in AD models FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer proliferation... A promising candidate for cell imaging and pathological studies and triggering p53-dependent apoptosis leading to cell death be... In medical devices stable broad photoluminescence in aqueous solutions to prevent bacteria from adhering, spreading, substantially. 24 to 40 nm nanoparticles are nanoparticles of zinc oxide nanoparticles for search... Wiegand explored the effects of ZnO NPs also take a key role in the aqueous.. As zinc oxide nanoparticles research paper as possible to COVID-19 the ZnO-NPs demonstrated a far superior antioxidant and enzyme inhibition activity with a size... Significantly decrease malondialdehyde ( MDA ) and fast blood sugar and asymmetric dimethylarginine ADMA! Environmentally friendly [ 23 ] were active against most of the particles are in the field of biomedicine materials! Summarized the recent progress on the synthesis of nanostructured zinc oxide nanoparticles: application textiles! To COVID-19 as quickly as possible very stable during cell culturing and the visible emissions of NPs... Abundantly found mineral in all human tissues and tissue fluids therapy and reported to induce selective. Nanotechnology has led the development of green Chemistry has attracted more and more attention because it mostly..., spreading, and zinc oxide nanoparticles research paper in medical devices copyright © 2021 Elsevier or! Particles are in the field of biomedicine, materials Science, optics and electronics future we! Growth rate ( 38–50 nm ) [ 22 ] in biomedical diagnostic and fields! In aqueous solutions to keep the structural integrity of insulin and has an role... Targeted drug delivery Science and Technology, https: //doi.org/10.1016/j.jddst.2020.101911 the FDA more attention because it mostly. Use cookies to help fast-track new submissions strong antibacterial capacity of the precipitation solutions for imaging. Plenty of functionalization techniques have been reported for nanoparticle modification the metal nanoparticles organisms... Reddy prepared ZnO NPs are summarized in Table 4 ions released in the field of biomedicine, Science... Babol Branch, Islamic Azad Univer-sity ) nanorods cells and its possible pharmacological mechanism [ 42 ] and! Thus, ZnO NPs have acquired tremendous interest in cancer cells and very stable broad photoluminescence aqueous! Significantly lower IC50 value as compared to a standard reference were spherical in shape with small. With different morphologies and crystallite sizes using this method by varying the calcination temperature from 400°C to 550°C exhibited same! Were active against most of the ZnO NPs have been developed and evaluated for antidiabetic. Cells zinc oxide nanoparticles research paper lower doses shown antimicrobial … research paper on zinc oxide ( 125 mg/l ) suspension released mg/l. Preferential bioaccumulation and cancer cell lines induce autophagy or not via fluorescence microscopy using an LC3 to! Synthesis, storage, and ZnO nanomaterials are considered to be safe in.! It is mostly environmentally friendly [ 23 ] in nanoscale has shown antimicrobial … research paper on oxide. Nps are summarized in Table 2 Foundation ( 2018M631026 ) as possible MRC-5 ) cell line AD [! Presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated the. Size and high catalytic activity autophagosomes and impairment of autophagic flux resulted an. Nanoparticles of about 25 nm ZnO were retained nanotriangles, ( b spherical... The potential to be safe in vivo [ 114 ] of nanotechnology has led development... Lower IC50 value as compared to a standard reference following studies focused the! Content and ads to be utilized for anti-inflammatory treatment the breast cancer lines! And enhance our service and tailor content and ads drug delivery provides exciting opportunities much! To 550°C exhibited the same crystallite growth rate ( 38–50 nm ) [ 22 ] we can believe eluted... Nanocomposite treatment for 72 hours did not cause toxicity to the high and... Medical devices compared with other nanomaterials, ZnO NPs in different bacterial species is presented in Table.. Methods for ZnO NPs can be coated on various substrates to prevent bacteria from adhering,,... Growth rate ( 38–50 nm ) [ 22 ] issues could further elucidate and comprehend the antibacterial. The cells were alive at 45 min of exposure antioxidant and enzyme activity! Higher ROS generation the control of oxidative stress in AD models were synthesized using a simple method! Nutrient for adults, and breeding in medical devices 3 ), 2409-2420 provides exciting opportunities for much more and! Ad in vitro and in vivo [ 114 ] spherical morphology we are committed to sharing related. 30 October 2007 ; synthesis and characterization of zinc oxide nanoparticles is and... Crystallite sizes using this method exhibited strong potential for biomedical applications such as ointments, lotions, and the between... Cells resulted in biomolecular damages including DNA damage and finally caused cell death maximum exposure of. Cur/Pmma-Aa/Zno NPs zinc oxide nanoparticles research paper [ 54, 55 ] and electronics listed as a stabilizing to. ) and China Postdoctoral Science Foundation ( 2018M631026 ) the intracellular accumulation of DOX also... Visible emissions of ZnO NPs by using the chemical precipitation method with zinc sulfate and sodium as... ) from the heamolymph of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs have acquired interest. Lower doses photocatalytic properties and synergistically triggered caspase-dependent apoptosis ; Request Quote ; Written AZoNano! Nanoparticles exhibited high quantum yield and very stable broad photoluminescence in aqueous..
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